منابع مشابه
Uridine 5'-Diphosphate-N-Acetylglucosamine: Glycoprotein N-Acetylglucosaminylphosphotransferase
Received for publication 29 January 1981 and in revised form 13 February 1981.
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Protein N-glycosylation is found in all domains of life and has a conserved role in glycoprotein folding and stability. In animals, glycoproteins transit through the Golgi where the N-glycans are trimmed and rebuilt with sequences that bind lectins, an innovation that greatly increases structural diversity and redundancy of glycoprotein-lectin interaction at the cell surface. Here we ask whethe...
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Surface glycoproteins regulate nearly every extracellular event and they are dynamic for cells to adapt to the ever-changing extracellular environment. These glycoproteins contain a wealth of information on cellular development and disease states, and have significant biomedical implications. Systematic investigation of surface glycoproteins will result in a better understanding of surface prot...
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HIV-1 envelope glycoprotein (Env) is the sole target for broadly neutralizing antibodies (bnAbs) and the focus for design of an antibody-based HIV vaccine. The Env trimer is covered by ∼90N-linked glycans, which shield the underlying protein from immune surveillance. bNAbs to HIV develop during infection, with many showing dependence on glycans for binding to Env. The ability to routinely asses...
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ژورنال
عنوان ژورنال: Molecular & Cellular Proteomics
سال: 2013
ISSN: 1535-9476
DOI: 10.1074/mcp.o112.026617